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. 2008 Dec 3;14:2190–2203.

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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cannabidiol reduces p38 MAPK activation and prevents cell death in the uveitic retina. A: Lipopolysaccharide (LPS) treatment of rats resulted in a significant increase in p38 MAPK activation at 24 h. CBD (5 mg/kg) treatment reduced this effect. Data from 2 animals in each group are shown (asterisk represents that it is significantly different at p<0.05 as compared to control), Similar results were obtained in 2 independent experiments. B: CBD blocked neuronal cell death, as detected by TUNEL analysis. Data shown is the mean±SEM of 3 animals in each group (asterisk represents that it is significantly different at p<0.05 as compared to control). C: Colocalization of phospho-p38 MAPK (red) and TUNEL+cells (green) in the retinal ganglion cell layer. CBD blocked LPS-induced activation of p38 MAPK and blocked neuronal cell death. D: CBD blocked LPS-induced caspase-3 expression that was detected by Western analysis in the uveitic retina. Data from 2 animals in each group are shown (asterisk represents that it is significantly different at p<0.05 compared to control). Similar results were obtained in 2 independent experiments.