Table 4 Genotypic association tests with each allele as the recessive risk allele (sporadic Parkinson's disease data).
| SNP ID | Allele major/minor | Distance | Gene position | Frequency of major allele | Recessive risk model of major allele | Recessive risk model of minor allele | |||
|---|---|---|---|---|---|---|---|---|---|
| Cases | Control s | p Value | Odds ratio | p Value | Odds ratio | ||||
| (95% CI) | (95% CI) | ||||||||
| rs1876488 | G/T | 72981628 | 0.809 | 0.825 | 0.410 | 0.73 (0.34 to 1.54) | 0.507 | 1.09 (0.83 to 1.44) | |
| rs1396107 | C/T | 72988240 | 0.708 | 0.751 | 0.464 | 0.82 (0.50 to 1.75) | 0.024 | 1.35 (1.03 to 1.75) | |
| rs1508060 | T/C | 72990328 | 0.716 | 0.756 | 0.486 | 0.83 (0.49 to 1.40) | 0.040 | 1.31 (1.01 to 1.71) | |
| rs1567230 | T/C | 72998602 | 0.897 | 0.931 | 0.817 | 1.21 (0.23 to 6.29) | 0.004 | 1.67 (1.16 to 2.37) | |
| rs2135985 | C/A | 73001132 | 0.899 | 0.928 | 0.625 | 1.48 (0.29 to 7.39) | 0.012 | 1.56 (1.09 to 2.20) | |
| rs4852902 | G/A | 73001656 | 0.898 | 0.927 | 0.624 | 1.48 (0.29 to 7.41) | 0.011 | 1.56 (1.10 to 2.20) | |
| rs2048170 | A/G | 73003323 | 0.900 | 0.926 | 0.590 | 1.53 (0.30 to 7.63) | 0.025 | 1.49 (1.04 to 2.12) | |
| rs1567229 | T/C | 73018249 | SPR promoter | 0.900 | 0.927 | 0.620 | 1.49 (0.30 to 7.45) | 0.017 | 1.52 (1.07 to 2.15) |
| rs1876491 | T/G | 73018800 | SPR promoter | 0.906 | 0.926 | 0.290 | 2.97 (0.35 to 24.7) | 0.049 | 1.42 (0.09 to 2.03) |
| rs2421095 | G/A | 73025179 | SPR promoter | 0.899 | 0.929 | 0.812 | 1.22 (0.23 to 6.32) | 0.011 | 1.57 (1.10 to 2.23) |
| rs1876487 | G/T | 73026007 | SPR promoter | 0.677 | 0.731 | 0.146 | 0.71 (0.45 to 1.15) | 0.015 | 1.38 (1.06 to 1.79) |
| rs6730083 | A/G | 73027652 | SPR intron 2 | 0.905 | 0.935 | 0.787 | 1.25 (0.24 to 6.49) | 0.008 | 1.16 (1.12 to 2.32) |
| rs1150500 | C/T | 73033098 | SPR 3′UTR | 0.901 | 0.930 | 0.987 | 0.98 (0.18 to 5.41) | 0.014 | 1.54 (1.08 to 2.19) |
| rs1161265 | A/G | 73033597 | SPR 3′UTR | 0.902 | 0.929 | 1.000 | 1.00 (0.18 to 5.48) | 0.025 | 1.49 (1.04 to 2.12) |
| rs1161267 | G/A | 73033836 | SPR 3′UTR | 0.904 | 0.930 | 0.970 | 0.97 (0.17 to 5.36) | 0.031 | 1.47 (1.03 to 2.10) |
| rs1561244 | G/A | 73041041 | 0.789 | 0.826 | 0.174 | 0.58 (0.27 to 1.27) | 0.078 | 1.28 (0.98 to 1.70) | |
| rs1561245 | C/T | 73042822 | 0.597 | 0.636 | 0.473 | 0.87 (0.60 to 1.26) | 0.060 | 1.29 (0.98 to 1.70) | |
| rs4852903 | G/C | 73043640 | 0.804 | 0.810 | 0.909 | 1.01 (0.77 to 1.34) | 0.468 | 0.78 (0.40 to 1.51) | |
| rs6745468 | G/C | 73061450 | EMX1 intron2 | 0.801 | 0.836 | 0.225 | 0.59 (0.25 to 1.39) | 0.068 | 1.29 (0.98 to 1.70) |
| rs999494 | G/A | 73069050 | EMX1 intron2 | 0.818 | 0.829 | 0.491 | 1.13 (0.83 to 1.46) | 0.993 | 1.00 (0.48 to 2.09) |
| rs6728203 | A/G | 73069674 | EMX1 | 0.765 | 0.800 | 0.532 | 0.86 (0.40 to 1.58) | 0.061 | 1.29 (0.98 to 1.68) |
| rs746212 | C/T | 7376889 | EMX1 | 0.687 | 0.705 | 0.140 | 0.72 (0.47 to 1.14) | 0.840 | 1.02 (0.78 to 1.33) |
| rs6722190 | C/G | 73080248 | EMX1 | 0.672 | 0.689 | 0.090 | 0.69 (0.46 to 1.06) | 1.000 | 1.00 (0.76 to 1.30) |
*SNP positions are based on human genome assembly (hg17) and NCBI build 35.
SNP, single nucleotide polymorphism; SPR, sepiapterin reductase gene.