Figure 2.
Mean threshold current levels needed to evoke forelimb movements on stimulation of the left cerebral motor cortex. For each animal, the threshold average was calculated from 4 stimulation points. Intracortical microstimulation of the motor cortex in normal adult rats evoked low threshold contralateral forelimb movements and high threshold ipsilateral movements. After stroke, the contralateral movement threshold (for right normal forelimb) was unchanged, whereas the ipsilateral movement threshold was significantly decreased at 6 weeks postischemia (P<0.001). BMSC treatment further reduced the threshold current needed for ipsilateral forelimb movement (P<0.05).