Table 2.

Frequent Clinical and Laboratory Features of IRIS by Pathogen

Condition	Clinical Features	Laboratory Features
CMV	blurred vision	Vitritis, uveitis
Cryptococcus	Aseptic meningitis, lymphadenitis, pneumonitis	Sterile cultures, decreased CRAG, elevated CSF pressure in ~75%.
Herpes viruses	exaggerated dermatologic lesions of HSV or VZV of various intensity	PCR positive
Hepatitis B	acute hepatitis	Increased LFTs.
Hepatitis C	rapid development of cirrhosis difficult to distinguish from hepatotoxicity	HBV/HCV viral loads typically decreased.
M. avium complex	lymphadenitis, draining sinuses Pulmonary-thoracic disease Abdominal lymphadenopathy	Granulomatous reaction, paucity of organisms, rare hypercalcemia Fever 66%, Prior diagnosis 25%
M. tuberculosis	lymphadenitis, pneumonitis	Paucity of AFB, PCR positive