TABLE 3.
Association between IL-1α −889-C/T, IL-4 −1098-G/T and −590-C/T, and IL-6 −174-G/C genotype distributions and chronic OM
| SNP and genotype | No. (%) of patients or control subjects with genotypea
|
|
|---|---|---|
| Patients (n = 81) | Control subjects (n = 110) | |
| IL-1α −889 C/T | ||
| CC | 42 (51.8) | 86 (78.2) |
| TC | 28 (34.6) | 21 (19.1) |
| TT | 11 (13.6) | 3 (2.7) |
| IL-4 | ||
| −1098 G/T | ||
| GG | 9 (11.1) | 80 (72.7) |
| GT | 62 (76.6) | 28 (25.5) |
| TT | 10 (12.3) | 2 (1.8) |
| −590 C/T | ||
| CC | 23 (28.4) | 88 (80) |
| CT | 51 (63) | 21 (19.1) |
| TT | 7 (8.6) | 1 (0.9) |
| IL-6 −174 G/C | ||
| GG | 35 (43.2) | 67 (61) |
| GC | 29 (35.8) | 38 (34.5) |
| CC | 17 (21) | 5 (4.54) |
a
P < 0.01 for all comparisons.