TABLE 3.
Colonization behaviors in relation to UTI status and other bacterial traits among 14 E. coli clones recovered from five human members and a canine member of a household over 3 yearsa
| Traitb (no. of clones with trait) | Median no. of samples/clone (range)
|
P value | Median no. of colonies/clone (range)
|
P value | Median no. of hosts/ clone (range)
|
P value | Median no. of time points/clone (range)
|
P value | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Trait present | Trait absent | Trait present | Trait absent | Trait present | Trait absent | Trait present | Trait absent | |||||
| UTI clone (2) | 11.5 (9-14) | 1 (1-7) | 0.01 | 42.5 (38-47) | 4.5 (1-21) | 0.02 | 5 (5-5) | 1 (1-3) | 0.01 | 4.5 (3-6) | 1 (1-4) | 0.04 |
| Group B2 (4) | 6 (1-14) | 1 (1-7) | 0.09 | 26.5 (5-47) | 4 (1-21) | 0.03 | 3.5 (1-5) | 1 (1-3) | 3 (1-6) | 1 (1-4) | ||
| pic (2) | 11.5 (9-14) | 1 (1-7) | 0.01 | 42.5 (38-47) | 4.5 (1-21) | 0.02 | 5 (5-5) | 1 (1-3) | 0.01 | 4.5 (3-6) | 1 (1-4) | 0.04 |
| usp (4) | 6 (1-14) | 1 (1-7) | 0.09 | 26.5 (5-47) | 4 (1-21) | 0.03 | 3.5 (1-5) | 1 (1-3) | 3 (1-6) | 1 (1-4) | ||
| clbB (3) | 9 (3-14) | 1 (1-7) | 0.01 | 38 (15-47) | 4 (1-21) | 0.01 | 5 (2-5) | 1 (1-3) | 0.01 | 3 (3-6) | 1 (1-4) | 0.02 |
| clbN (2) | 8.5 (3-14) | 1 (1-9) | 0.066 | 31 (15-47) | 4.5 (1-38) | 0.088 | 3.5 (2-5) | 1 (1-5) | 0.099 | 4.5 (3-6) | 1 (1-4) | 0.04 |
| malX (6) | 2.5 (1-14) | 1 (1-7) | 10 (5-47) | 4 (1-21) | 0.03 | 2 (1-5) | 1 (1-3) | 2 (1-6) | 1 (1-4) | |||
Samples, total of number of samples that yielded the clone at any time during the study; colonies, total number of colonies accounted for by the clone during the study; hosts, total number of hosts that yielded the clone at any time during the study; time points, number of sampling points at which the clone was encountered in one or more hosts.
The traits shown are those that yielded P < 0.05 by the Mann-Whitney U test (exact, two tailed) for an association with one or more of the colonization behavior endpoints. P values of <0.10 are shown. UTI clone, urine isolate from mother's or dog's acute UTI episode. Group B2, phylogenetic group B2; pic, protein involved in colonization (serine protease); usp, uropathogenicity-specific protein; clbB and clbN, colibactin synthesis; malX, pathogenicity island marker. Additional traits that yielded only borderline associations (0.10 > P > 0.05) with one or more of the colonization behaviors included sfa/foc (S and F1C fimbriae; P = 0.07 for dates, samples, and colonies) and the H7 fliC allele (flagellin; P = 0.099 for hosts, P = 0.088 for samples). No assessed trait yielded a borderline or significant negative association with any of the colonization behavior endpoints.