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. 2008 Oct 1;82(24):12020–12029. doi: 10.1128/JVI.01569-08

FIG. 5.

FIG. 5.

Analysis of JFH-1 wt and G451R buoyant density. Concentrated JFH-1 wt and G451R were separated on an iodixanol gradient. (A) The number of HCV particles per fraction was assessed by quantifying HCV RNA genomes by RT-PCR. The particle number in each fraction is expressed as a percentage of the total for either virus. (B) The infectivity per fraction was assessed by inoculating Huh-7.5 cells. The infectivity within each fraction is expressed as a percentage of the total for either virus. Error bars indicate standard deviations from the mean (n = 3). (C) The number of infectious units per RNA genome copy were calculated to analyze the specific infectivity of particles within each fraction.