TABLE 1.
ORF | Amino acid positions | Peptide sequence | Proposed function | Restriction element | Response type | Gene expression | % CD8+/MHC-PE+ at day:
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6
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10
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Mean | SD | Mean | SD | |||||||
ORF75c | 940-947 | KSLTYYKL | Tegument protein/FGARATc | H-2Kb | E | L | 4.513 | 1.311 | 3.673 | 0.691 |
ORF39 | 167-174 | FVYLFHFM | Virion membrane glycoprotein M | H-2Kb | E | L | 1.927 | 0.121 | 1.530 | 1.530 |
ORF48 | 148-155 | TNYKFSLV | Hypothetical protein | H-2Kb | E | E | 1.103 | 0.166 | 1.027 | 0.130 |
ORF56 | 108-115 | SCLDYSHL | Component of herpesvirus helicase-primase complex | H-2Kb | E | L | 0.520 | 0.325 | 0.260 | 0.060 |
ORF62 | 272-279 | RSYIYYAL | Capsid assembly and DNA maturation protein | H-2Kb | E | E-L | 0.443 | 0.021 | 0.223 | 0.085 |
ORF26 | 132-139 | VNLVFPSV | Capsid protein | H-2Kb | E | L | 0.400 | 0.036 | 0.203 | 0.068 |
ORF7 | 491-498 | LGSVYYKL | DNA packaging and transport protein | H-2Kb | E | E | 0.310 | 0.191 | 0.223 | 0.045 |
ORF75c | 935-942 | AILKFKSL | Tegument protein/FGARATc | H-2Kb | E | L | 0.283 | 0.075 | 0.128 | 0.020 |
ORF9 | 682-689 | SVYGFTGV | DNA polymerase family B | H-2Kb | E | E | 0.233 | 0.104 | 0.200 | 0.066 |
ORF58 | 124-131 | CNRIYARL | Hypothetical protein | H-2Kb | E | E-L | 0.173 | 0.042 | 0.165 | 0.010 |
ORF61 | 524-531 | TSINFVKI (p79) | Ribonucleotide reductase, large subunit | H-2Kb | L | E | 1.640 | 0.308 | 8.953 | 2.673 |
ORF8 | 604-612 | KNYIFEEKL | Virion membrane glycoprotein B | H-2Kb | L | L | 0.650 | 0.125 | 2.410 | 0.596 |
ORF61 | 164-171 | ITYFFEMI | Ribonucleotide reductase, large subunit | H-2Kb | L | E | 1.127 | 0.204 | 1.937 | 0.049 |
ORF54 | 253-260 | AVVQFIRV | dUTPase | H-2Kb | L | E | 0.663 | 0.572 | 1.700 | 0.729 |
ORF25 | 524-531 | LSPPMAHL | Herpesvirus major capsid protein | H-2Kb | L | L | 0.237 | 0.031 | 1.353 | 0.942 |
ORF6 | 15-22 | AGYIYYQL | Major ssDNAa binding protein | H-2Kb | L | E | 0.240 | 0.053 | 0.333 | 0.241 |
ORF21 | 304-311 | TGFRYSYM | Herpesvirus thymidine kinase | H-2Kb | L | E | 0.142 | 0.041 | 0.193 | 0.071 |
ORF59 | 74-81 | AIYSFRNA | DNA polymerase, processivity subunit | H-2Kb | L | E | 0.180 | 0.060 | 0.137 | 0.141 |
ORF75c | 176-184 | SAIENYETF | Tegument protein/FGARATc | H-2Db | E | L | 0.870 | 0.421 | 0.343 | 0.083 |
ORF6 | 487-495 | AGPHNDMEI (p56) | Major ssDNA binding protein | H-2Db | L | E | 2.020 | 0.567 | 3.710 | 1.141 |
ORF17 | 308-316 | SAITNHAAF | Capsid protein | H-2Db | L | L | 0.473 | 0.207 | 0.933 | 0.435 |
ORF6 | 164-172 | SAPMKTVTI | Major ssDNA binding protein | H-2Db | L | E | 0.197 | 0.074 | 0.203 | 0.057 |
Total % | 18.344 | 29.837 |
ssDNA, single-stranded DNA.