TABLE 3.

Mutation frequency of FMDV WT and M296I 3Dpol

FMDV type	Biochemical			Biological
	Mutation frequencya			Transition mutation frequencyb
	Transitionc	Ribavirin with s/s-AUd	Ribavirin with s/s-ACe	Without ribavirin	With ribivarin
WT	1/20,000	1/4,000	1/100,000	1/3,254	1/862
M296I	1/8,000	1/8,000	1/100,000	1/2,440	1/938

^aAll values are rounded to one significant figure. The error in each measurement is no greater than 20%.

^bValues were calculated from data presented in Sierra et al. (39).

^cTransition mutation frequency is calculated as (k_{pol incorr}/K_{d,app incorr})/(k_{pol corr}/K_{d,app corr}), using the k_pol and K_d,app values for ATP and GTP as the correct (corr) or incorrect (incorr) nucleotide for s/s-AU.

^dRibavirin mutation frequency is calculated as (k_{pol RTP}/K_{d,app RTP})/(k_polATP/K_{d,app ATP}).

^eRibavirin mutation frequency is calculated as (k_{pol RTP}/K_{d,app RTP})/(k_{pol GTP}/K_{d,app GTP}).