FIG. 1.

EBNA1 domains and mutants. Schematic representation of the wild-type EBNA1 protein is shown on top along with some of the functional elements, nuclear localization signal (NLS), and amino acid numbers. A version of the EBNA1 protein lacking most of the glycine-alanine repeat sequence was used in these studies (EBNA1) and retains all EBNA1-associated activities. EBNA1 deletion mutants are also shown along with a summary of their previously determined activities in DNA replication (Repl), segregation (Segr), and transcriptional activation (Trans) from the work of Shire et al. (45), Ceccarelli and Frappier (12), and Wu et al. (58), where + denotes complete activity, +/− denotes partial activity, − denotes no activity, and ND means “not determined”.