FIG. 6.

Model of amino acid substitutions at position 326 in domain III of the YF5.2iv E protein. (Left) Structure of YF5.2iv (top) and the 326R substitution (bottom). (Right, top) Structure of 326E or 326D (the 326E model is shown, as the models for D and E substitutions are very similar). (Right, bottom) Model for 326G, 326Q, 326S, or 326A. The model for 326Q is shown, as it is representative of the models for the other substitutions, with slightly smaller neutral space filling at position 326 for side chain residues other than Q (data not shown).