TABLE 1.
Total BAL cell numbers during primary RSV infectiona
| Treatment group | Total BAL cell count (SE)
|
||||
|---|---|---|---|---|---|
| Day 0 | Day 2 | Day 4 | Day 6 | Day 8 | |
| PBS | 2.9 × 104 (0.5) | 6.0 × 105 (1.5)† | 6.5 × 105 (1.5)† | 1.2 × 106 (3.1)† | 7.0 × 105 (1.2)† |
| MM | 3.1 × 104 (0.8) | 5.8 × 105 (2.1)† | 7.9 × 105 (2.8)† | 1.4 × 106 (30.5)† | 8.0 × 105 (1.5)† |
| WT | 3.0 × 104 (0.5) | 3.9 × 105 (0.5)*† | 3.8 × 105 (0.2)*† | 0.5 × 106 (3.5)*† | 6.5 × 105 (1.1)† |
a
Mice were i.n. treated with PBS, 100 nM (2 mg/kg) MM siRNA (MM), or 100 nM (2 mg/kg) WT siRNA (WT) specific for the RSV P gene prior to RSV/A2 infection (106 PFU). The total cell numbers were determined from three to five mice/treatment in three separate experiments. *, Statistically different (P < 0.05) from MM- and PBS-treated mice; †, statistically different (P < 0.05) from day 0 response.