TABLE 2.

Total number of cell types in the BAL during the primary response to RSV infection^a

Cell type and day p.i.	Total no. of cells (SE)
	WT	MM	PBS
CD4+
2	1.5 × 103 (3.0)	3.1 × 103 (2.2)	2.5 × 103 (1.5)
4	16.5 × 103 (3.1)	18.5 × 103 (2.5)	14.4 × 103 (2.8)
6	16.2 × 103 (2.1)	16.0 × 103 (2.4)	12.2 × 103 (1.6)
8	33.5 × 103 (5.8)	29.5 × 103 (6.0)	31.0 × 103 (5.2)
CD8+
2	2.8 × 103 (1.1)	5.8 × 103 (2.2)	5.1 × 103 (1.5)
4	18.5 × 103 (1.8)	17.9 × 103 (2.8)	18.9 × 103 (2.8)
6	18.4 × 103 (2.5)	21.0 × 103 (2.1)	19.4 × 103 (2.6)
8	48.6 × 103 (5.5)	39.5 × 103 (5.7)	48.0 × 103 (5.5)
B220+
2	0.09 × 103 (0.1)	0.1 × 103 (0.1)	0.1 × 103 (0.1)
4	0.5 × 103 (0.1)	0.2 × 103 (0.1)	0.8 × 103 (0.1)
6	0.5 × 103 (0.5)	0.6 × 103 (0.2)	0.5 × 103 (0.1)
8	0.3 × 103 (0.1)	0.1 × 103 (0.1)	0.6 × 103 (0.2)
DX5+
2	2.5 × 103 (0.5)†	5.0 × 103 (1.1)	4.8 × 103 (1.2)
4	5.0 × 103 (0.5)	8.0 × 103 (1.2)	6.5 × 103 (1.3)
6	7.5 × 103 (1.2)†‡	14.4 × 103 (2.8)‡	1.3 × 103 (1.1)†
8	1.9 × 103 (1.1)†	7.0 × 103 (1.2)	0.5 × 103 (0.5)†
RB6-8C5+
2	3.8 × 103 (0.8)†‡	11.8 × 103 (1.8)*	10.0 × 103 (1.5)*
4	1.9 × 103 (0.8)	2.5 × 103 (1.8)	3.3 × 103 (2.5)
6	5.8 × 103 (2.4)	6.0 × 103 (1.8)	7.4 × 103 (2.0)
8	8.8 × 103 (1.4)	8.0 × 103 (2.7)	9.8 × 103 (0.4)
CD11b+
2	3.1 × 103 (0.5)†‡	5.9 × 103 (0.5)	5.1 × 103 (0.5)
4	10.0 × 103 (2.8)	10.8 × 103 (2.8)	11.0 × 103 (2.2)
6	5.0 × 103 (1.2)	4.1 × 103 (1.5)	5.9 × 103 (1.5)
8	5.5 × 103 (1.8)†	9.0 × 103 (1.1)	7.5 × 103 (1.5)

^aMice were i.n. treated with 100 nM (2 mg/kg) WT siRNA specific for the RSV P gene, 100 nM (2 mg/kg) MM siRNA, or PBS prior to RSV/A2 infection (10⁶ PFU). The total cell numbers were determined from four to five mice/treatment in three separate experiments using appropriate monoclonal antibodies and flow cytometry. *, Statistically different (P < 0.05) from WT-treated mice; †, statistically different (P < 0.05) from MM-treated mice; ‡, statistically different (P < 0.05) from PBS-treated mice.