TABLE 3.
Total BAL cell numbers after RSV challenge of immune micea
| Treatment group | Total no. of cells (SE)
|
|||||
|---|---|---|---|---|---|---|
| Day 0 | Day 2 | Day 4 | Day 6 | Day 8 | Day 10 | |
| PBS | 0.8 × 104 (0.5) | 5.5 × 105 (1.1) | 6.0 × 105 (1.4) | 7.2 × 105 (2.1) | 6.2 × 105 (1.2) | 2.1 × 105 (1.2) |
| MM | 0.5 × 104 (0.5) | 5.2 × 105 (1.2) | 6.7 × 105 (1.0) | 6.9 × 105 (20.0) | 6.9 × 105 (1.1) | 2.3 × 105 (1.5) |
| WT | 0.4 × 104 (0.5) | 5.2 × 105 (1.2) | 5.8 × 105 (1.2) | 9.6 × 105 (0.8)*† | 7.4 × 105 (1.3) | 2.0 × 105 (1.0) |
a
Mice prophylactically treated with WT or MM siRNA or PBS and i.n. infected with 106 PFU RSV/A2 were rested for 3 weeks p.i. and then i.n. challenged with 106 PFU of RSV/A Long. BAL cells were collected at the days indicated postchallenge. The total cell numbers were determined from four to five mice/treatment in three separate experiments. *, Statistically different (P < 0.05) from MM-treated mice; †, statistically different (P < 0.05) from PBS-treated mice.