TABLE 3.
Comparison of the ability of the target cell-limited model and variants including anti-gp41 antibodies to fit early plasma VL kinetic data
| Subject no. | Fit of the indicated model (P value)a
|
Best-fitting model | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CE model:
|
ID model
|
CDE model
|
||||||||
| IgG | IgM | IgG+IgM | IgG | IgM | IgG+IgM | CDE IgG | CDE IgM | CDE IgG+ IgM | ||
| 6240 | 0.320 | 0.326 | 0.266 | 0.975 | 0.977 | 0.975 | 0.975 | 0.975 | 1.000 | Target cell limited |
| 6246 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | Target cell limited |
| 9032 | 0.004 | 0.006 | 0.001 | 0.005 | 0.006 | 0.006 | 0.89 | 0.011 | 0.923 | CE or ID |
| 9077 | 0.567 | 0.998 | 0.687 | 0.604 | 0.998 | 0.623 | 0.722 | 0.998 | 0.991 | Target cell limited |
| 9079 | 0.992 | 0.994 | 0.960 | 0.998 | 0.649 | 0.992 | 0.964 | 0.070 | 0.598 | Target cell limited |
| 12008 | 0.566 | 0.607 | 0.590 | 0.648 | 0.546 | 0.657 | 1.000 | 1.000 | 1.000 | Target cell limited |
a
The VL data from each donor was fit using the target cell-limited model and models that incorporated the effects of anti-gp41 IgG or IgM and IgG plus IgM. CE, clearance enhanced; ID, infectivity diminished; CDE, cell death enhanced. The models with antibody effects include one additional parameter, which when set to zero reduces the model to the target cell-limited model. An F-test was used to determine if any of the models including antibody fit the VL data significantly better than the target cell-model. The table gives the P values computed from the F-test.