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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Drug Metab Dispos. 2008 Aug 21;36(11):2244–2251. doi: 10.1124/dmd.108.022996

Fig. 2.

Fig. 2

The renal clearance (CLR), metabolic clearance (CLm), and total clearance (CLT) of GHB determined after the concomitant treatment with D-mannitol, L-lactate, or D-mannitol/L-lactate. The control was administered with GHB (208 mg h−1 kg−1) only. L-Lactate was administered at a dose of 60.5 mg h−1 kg−1 by i.v. infusion, D-mannitol was administered as an i.v. bolus dose of 0.5 g/kg, and Man + Lact represents the combined treatment with D-mannitol and L-lactate. One-way ANOVA followed by Dunnett's test, n = 3-8, mean ± S.D. **, p < 0.01.