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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Drug Metab Dispos. 2008 Aug 21;36(11):2244–2251. doi: 10.1124/dmd.108.022996

Fig. 4.

Fig. 4

Plasma concentrations of GHB after treatment with GHB alone or with concomitant lactated Ringer's solution, D-mannitol, or lactated Ringer's solution/D-mannitol administration. The control was administered GHB (1000 mg/kg, i.v. bolus) only, followed by i.v. infusion of saline at the rate of 300 µl/min; L-lactate represents the i.v. infusion of lactated Ringer's solution at the rate of 300 µl/min; D-mannitol represents the 0.5g/kg bolus dose of D-mannitol; and Man + Lact represents the combined treatment with D-mannitol 0.5g/kg and i.v. infusion of lactated Ringer's solution at the rate of 300 µl/min, n = 3 to 4 per group.