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. Author manuscript; available in PMC: 2009 Jul 31.
Published in final edited form as: Neuron. 2008 Jul 31;59(2):288–297. doi: 10.1016/j.neuron.2008.05.024

Figure 5.

Figure 5

Extinction training and reinstatement did not reduce synaptic potentiation in VTA DA synapses after cocaine self-administration. Behavioral responses in rats that underwent (A) 3 weeks of extinction training or (B) 3 wks extinction followed by 2 hr of cue-induced reinstatement. Error bars were removed for clarity. AMPAR/NMDAR ratios (C) and mEPSC frequency (D) remained elevated after 3 weeks of extinction and extinction/reinstatement. (E) mEPSC amplitude was not altered after extinction and extinction/reinstatement. Cumulative probability of frequency (F) and amplitude (G) of example cells from Ext and Reinst groups in comparison with Naive rats. Dotted line represents averages from Naive rats. *p < 0.05 versus Naïve rats.