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. 2008 Oct 6;28(24):7487–7503. doi: 10.1128/MCB.00799-08

TABLE 5.

Genes associated with same number of ERα binding sites but differentially regulated by estrogena

GenBank no. Gene symbol Strand No. of E2 inducible binding sites Fold change
Differential expression between MCF-7p and MCF-7AKT cells P
MCF-7p MCF-7AKT
NM_013319 UBIAD1 + 1 1.88* 2.18* 1.16 2.4E-02
NM_025077 TOE1 + 2 1.32* 1.59* 1.20 1.8E-02
NM_004428 EFNA1 + 2 0.35* 0.32* 0.91 2.2E-02
NM_002928 RGS16 − 1 1.42* 1.70* 1.19 3.2E-02
NM_001030287 ATF3 + 1 1.27* 1.68* 1.32 4.2E-03
NM_000399 EGR2 − 1 0.97 1.16* 1.19 2.9E-02
NM_018649 H2AFY2 + 1 1.07 1.34* 1.26 5.9E-04
NM_019058 DDIT4 + 1 0.66* 0.88 1.32 7.4E-03
NM_138706 B3GNT6 + 2 1.12* 0.94* 0.84 2.0E-03
NM_000926 PGR − 1 2.27* 3.14* 1.38 8.0E-05
NM_003979 GPRC5A + 1 0.72* 0.95 1.32 2.6E-02
NM_005967 NAB2 + 2 1.07 1.24* 1.16 3.6E-02
NM_079836 TUBA3C − 1 1.35* 1.68* 1.24 6.7E-03
NM_005766 FARP1 + 3 1.52* 1.76* 1.16 2.7E-02
NM_014045 LRP10 + 1 0.86* 0.99 1.16 2.2E-02
NM_014584 ERO1L − 1 1.20* 1.38* 1.15 3.8E-02
NM_024071 ZFYVE21 + 2 1.29* 1.49* 1.16 2.5E-02
NM_207419 C1QTNF8 − 2 1.13* 1.02 0.90 4.4E-02
NM_138440 VASN + 3 0.90 1.17 1.30 4.1E-02
NM_001025604 ARRDC2 + 2 0.92 1.04 1.13 4.0E-02
NM_033103 RHPN2 − 1 1.20* 1.44* 1.20 9.0E-03
NM_014681 DHX34 + 2 1.09* 1.23* 1.13 3.6E-02
NM_000979 RPL18 − 1 0.90* 0.97 1.08 2.9E-02
NM_005253 FOSL2 + 1 0.95 1.15* 1.22 2.6E-02
NM_199227 MAP1D + 1 1.02 0.87* 0.85 1.0E-02
NM_024893 C20orf39 + 1 3.59* 3.26* 0.91 3.4E-02
NM_021809 TGIF2 + 1 2.27* 2.63* 1.16 3.2E-02
NM_005423 TFF2 − 1 1.52* 2.42* 1.59 8.0E-05
NM_001006114 C21orf57 + 1 0.92 1.04 1.13 3.9E-02
NM_007061 CDC42EP1 + 1 1.46* 1.76* 1.21 4.7E-02
NM_003670 BHLHB2 + 1 2.02* 3.00* 1.48 2.9E-02
NM_024513 FYCO1 − 1 0.86* 0.75* 0.88 3.7E-02
NM_002841 PTPRG + 1 0.88 1.09 1.25 2.4E-02
NM_182920 ADAMTS9 − 1 1.11 1.45* 1.30 3.0E-03
NM_152773 MGC33212 − 1 0.99 0.86* 0.87 4.6E-02
NM_013409 FST + 2 1.05 1.27* 1.21 1.5E-02
NM_000358 TGFBI + 1 0.78* 0.93 1.18 2.2E-03
NM_000679 ADRA1B + 1 0.78* 0.97 1.25 4.6E-02
NM_178012 TUBB2B − 1 8.86* 13.92* 1.57 2.1E-04
NM_006638 RPP40 − 1 1.62* 1.83* 1.13 1.4E-02
NM_021922 FANCE + 1 1.20* 1.38* 1.15 1.2E-02
NM_022917 NOL6 − 1 1.91* 2.30* 1.20 3.1E-02
NM_017881 C9orf95 − 1 2.07* 2.38* 1.15 1.8E-02
NM_017443 POLE3 − 1 1.35* 1.50* 1.11 2.4E-02
NM_001633 AMBP − 2 1.11* 1.30* 1.17 4.1E-02
a

Differential expression in MCF-7p and MCF-7AKT cells of >1: estrogen-induced gene upregulation is greater in MCF-7AKT cells than in MCF-7p cells or estrogen-mediated downregulation is greater in MCF-7p cells than in MCF-7AKT cells. Differential expression in MCF-7p and MCF-7AKT cells of <1: estrogen-induced gene upregulation is greater in MCF-7p cells than in MCF-7AKT cells or estrogen-mediated downregulation is greater in MCF-7AKT cells than in MCF-7p cells. *, genes whose expression was significantly different in untreated and estrogen-treated cells. Genes with a change of >1 are inducible genes, and genes with a change of <1 are repressed genes.