FIG. A1.

Alternative splicing events in human and mouse GTPBP3. The consensus splicing sequences in intron 7, the alternative acceptor site in exon 8A, and the polypyrimidine tracks upstream from exon 8A and 8B are shown. The exon/intron boundaries are indicated by vertical sticks. Splice donor and acceptor sites are indicated in bold uppercase letters. Note that the first nucleotide of exon 8B is a pyrimidine and not the more frequent guanine, which is indeed present as the first nucleotide of exon 8A. Sequences including putative branch sites (underlined) and polypyrimidine tracts are denoted in lowercase letters. Purines interrupting polypyrimidine tracts are indicated in bold italics. Amino acid sequences resulting from each splicing variant are denoted by one-letter amino acid code below the corresponding nucleotide sequence.