Fig. 8.

A: the ratio of NO concentration to the concentration of ONOO⁻ (R = [NO]/[ONOO⁻]). NO and ONOO⁻ releases were stimulated by CaI (1 μmol/l) from endothelial cells of the aortas of C57BL/6J mice maintained for 105 days on low-calorie diet (1) or on high-calorie (60 kcal fat) diet (2) with supplementation of l-arginine (100 mg·kg⁻¹·day⁻¹) (3) or with supplementation with l-arginine (100 mg·kg⁻¹·day⁻¹) and sepiapterin (10 mg/kg/day) (4). *P < 0.01 vs. control (low-calorie diet); #P < 0.05 vs. obese mice without supplementation with l-arginine or l-arginine and sepiapterin; n = 5 mice. B: l-arginine concentration in serum and aortic endothelium of C57BL/6J mice maintained for 105 days on low-calorie diet (1) or on high-calorie (60 kcal fat) without (2) or with supplementation with l-arginine (100 mg·kg⁻¹·day⁻¹) (3). *P < 0.01 vs. control (low-calorie diet); #P < 0.05 vs. obese mice without supplementation with l-arginine; n = 5 mice.