Table 1.
Basal myocardial function assessed by Langendorff perfusion system
| Control | PI3Kα | P Value | |
|---|---|---|---|
| n | 5 | 6 | |
| LV developed pressure, mmHg | 125.4±4.5 | 148.2±6.5* | 0.022 |
| LVdP/dtmax | 3,066±125 | 3,619±108* | 0.008 |
| LVdP/dtmin | 3,000±142 | 3,500±105* | 0.018 |
| Heart rate, beats/min | 335±25 | 323±20 | 0.716 |
| Coronary flow rate, ml/min | 3.72±0.15 | 3.27±0.30 | 0.234 |
Values are means ± SE; n, no. of littermates/group. Male double transgenic littermates (3 to 4 mo old) were maintained with doxycycline (control) or regular water [phosphatidylinositol 3-kinase (PI3K)α] for 2 wk before measurement.
*
P < 0.05. LVdP/dtmax and LVdP/dtmin, the maximal and minimal positive values of the first derivative of left ventricular (LV) pressure, respectively.