Fig. 4.

Representative immunoblots of phosphorylated protein expression in hearts that underwent no experimental protocol (non-POC), POC, or POC + 20 μM AG 490 (POC + AG). A: AG 490 treatment did not significantly reduce p-STAT3 expression compared with POC hearts without AG 490. *P = 0.04 vs. non-POC; **P = 0.02 vs. non-POC. B: similarly, expression of p-Akt was not significantly reduced following AG 490 treatment compared with POC hearts without the inhibitor. *P = 0.003 vs. non-POC; **P = 0.006 vs. non-POC.