Fig. 6.

Cardiovascular responses to graded activation of chemically sensitive afferent fibers. A: injection of capsaicin into the arterial supply of hindlimb skeletal muscle elicited pressor responses that were positively correlated to the dose of capsaicin administered in both WKY and SHR rats (P < 0.01). B: when MAP was plotted against the log of the capsaicin dose, this relationship remained. In A and B, when regression analyses were applied, the slopes of the relationships were significantly greater in SHR compared with WKY. C: HR was likewise found to be positively correlated to the dose of capsaicin administered in each group of animals (P < 0.01). D: when HR was plotted against the log of the capsaicin dose, this relationship was again the same. When regression analyses were applied in C and D, the slopes of the relationships were not different between SHR and WKY. In A–D, all data points within a group were used to determine the correlation coefficient (r) and regression slope. Data were averaged for presentation only.