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. 2008 Dec;72(4):642–671. doi: 10.1128/MMBR.00020-08

FIG. 9.

FIG. 9.

Crystal structure of the RecB helicase domain. (A) Cartoon representation of the RecB helicase domain showing the four subdomain structures characteristic of SF1 DNA helicases. The nuclease domain, which is attached via a long linker, is partially shown in magenta. The DNA substrate is shown in deep purple. (B) RecB helicase with the location of the seven conserved helicase “signature” motifs shown. (C) Surface representation colored as described above for A. Note the cleft at the interface of subdomains 1A and 2A, which forms the ATP-binding pocket. Also particularly evident is the 70-amino-acid linker that connects the helical domain to the nuclease (Nuc) domain (the linker is colored rose and runs upward from left to right). (D) Surface representation colored as described above for B. Note that the helicase motifs line the ATP binding cleft and extend to the ssDNA binding site that is formed across the top surface of subdomains 1A and 2A.