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. 2008 Dec;72(4):590–641. doi: 10.1128/MMBR.00016-08

TABLE 3.

Leucinostatins and efrapeptins

Name	Molecular formula	Source	Synonyms	Inhibitory potency (reference)
Leucinostatin	A, C₆₂H₁₁₁N₁₁O₁₃; B, C₆₁H₁₀₉N₁₁O₁₃; C, C₆₀H₁₀₇N₁₁O₁₃; D, C₅₆H₁₀₁N₁₁O₁₁; H, C₅₇H₁₀₃N₁₁O₁₂; K, C₆₂H₁₁₁N₁₁O₁₄	A, P. lilacinus, P. marquandii, and P. abruptus; B, P. lilacinus and P. marquandii; C, P. lilacinus; D, P. lilacinus and P. marquandii; H and K, P. marquandii	A, A20668, paecilotoxin A, CC-1014; B, paecilotoxin B; C, paecilotoxin C; D, paecilotoxin D; H, paecilotoxin H; K, paecilotoxin K	11 μg/mg protein^a (Crithidia asciculate SMP-ATPase) (439); 2 μg inhibitor/ml^a (spinach chloroplast, photophosphorylation) (242); 0.1-0.4 μg/mg protein (rat liver mitochondria, ATPase) (328)
Efrapeptin	C, C₈₀H₁₃₇N₁₈O₁₆⁺; D, C₈₁H₁₃₉N₁₈O₁₆⁺; E, C₈₂H₁₄₁N₁₈O₁₆⁺; F, C₈₂H₁₄₁N₁₈O₁₆⁺; G, C₈₃H₁₄₃N₁₈O₁₆⁺	Tolypocladium species	Efrastatin, A23871	0.56 mol/mol F₁^a (bovine heart MF₁-ATPase) (83); 70 ng/ml^a (C. asciculate MF₁-ATPase) (173); 0.3 μM^a (human umbilical vein endothelial cell, nonmitochondrial ATP synthase, ATP synthesis) (17); 0.5 μg/ml^a (R. rubrum chromatophores, photophosphorylation) (241); 0.05-0.5 μg of inhibitor/mg protein^a (T. pyriformis SMP-ATPase) (404); 21.5 μM^b (EF₁-ATPase) (436); 10 nM^c (bovine heart MF₁-ATPase) (83); complete inhibition at 2.4 mol inhibitor/mol enzyme (bovine heart SMP-ATPase and ATP synthesis) (83)

^a

I₅₀.

^b

K_i.

^c

K_d.