TABLE 9.
Organotin compounds and structural relatives
| Name | Molecular formula | Other names | Inhibitory potency (reference) |
|---|---|---|---|
| Tributyltin chloride | C12H27ClSn | TBT-Cl; tributylchlorostannane; chlorotributyltin; tri-n-butyltin chloride; monochlorotributyltin; tri-n-butylchlorotin; tributylstannyl chloride | 200 nMb (E. coli and I. tartaricus F0F1-ATPase) (418); 47% inhibition at 1 μM and 87% inhibition at 5 μM (C. thermoaceticum membrane-bound F0F1-ATPase) (190); 80% inhibition at 1 μM (TF0F1-ATPase) (403) |
| Tricyclohexyltin hydroxide | C18H34OSn | Cyhexatin; tricyclohexylhydroxytin; hydroxytricyclohexylstannane; tricyclohexylhydroxystannane; tricyclohexylstannanol; Plictran; tricyclohexylstannium hydroxide | 92.9% inhibition at 37 μM (rat liver MF0F1-ATPase) (252) |
| Triethyltin sulfate | C12H30O4SSn2 | Triethylstannium hydrogen sulfate; bis(triethyltin) sulfate; triethylhydroxytin sulfate | 0.13 μg of inhibitor/mg proteina (S. cerevisiae SMP-ATPase) (150, 151); 3-7 μg of inhibitor/mg proteina (T. pyriformis SMP-ATPase) (404); 1.2 μg/mg proteina (C. asciculate SMP-ATPase) (439) |
| Triphenyltin chloride | C18H15ClSn | Chlorotriphenylstannane; chlorotriphenyltin; triphenylchlorotin | <10 μMa (bovine heart SMP-ATPase) (437) |
| Dimethyltin 3-hydroxyflavone chloride | C17H15ClO3Sn | 12-13 nmol inhibitor/mg proteina (rat liver SMP-ATPase) (405) | |
| Diethyltin 3-hydroxyflavone chloride | C19H19ClO3Sn | 1.5 nmol inhibitor/mg proteina (rat liver SMP-ATPase) (405) | |
| Dibutyltin 3-hydroxyflavone bromide | C23H27BrO3Sn | 0.7-0.9 nmol inhibitor/mg proteina (rat liver SMP-ATPase) (405) | |
| Dioctyltin 3-hydroxyflavone chloride | C31H43ClO3Sn | 12-13 nmol inhibitor/mg proteina (rat liver SMP-ATPase) (405) | |
| Diphenyltin 3-hydroxyflavone chloride | C27H19ClO3Sn | 1.5 nmol inhibitor/mg proteina (rat liver SMP-ATPase) (405) | |
| Diethyltin 3,5,7,2′,4′-pentahydroxy flavone chloride | C19H19ClO7Sn | 5-6 nmol inhibitor/mg proteina (rat liver SMP-ATPase) (405) | |
| Dibutyltin 3,5,7,2′,4′-pentahydroxy flavone bromide | C23H27BrO7Sn | 0.6-0.8 nmol inhibitor/mg proteina (rat liver SMP-ATPase) (405) | |
| Diphenyltin 3,5,7,2′,4′-pentahydroxy flavone chloride | C27H19ClO7Sn | 3.5-4 nmol inhibitor/mg proteina (rat liver SMP-ATPase) (405) | |
| Tributyltin 3-hydroxyflavone | C27H36O3Sn | 1.5-2 nmol inhibitor/mg proteina (rat liver SMP-ATPase) (405) | |
| Triethyllead | C6H15ClPb | Triethylplumbane | 16-17 μMa (rat liver SMP-ATPase) (275) |
a
I50.
b
Ki.