Table 2.
Univariate and multivariate analyses of the relation between age and specific mortality for renal cell carcinoma after nephrectomy
| Univariate
|
Multivariate
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Predictors | RR (p value) | Overall RR (p value) | Stage I RR (p value) | Stage II RR (p value) | Stage III RR (p value) | Stage IV RR (p value) | ||||||
| Age at diagnosis* | — | (< 0.001) | — | (< 0.001) | — | (0.002) | — | (0.033) | — | (< 0.001) | — | (< 0.001) |
| Sex | — | (0.004) | — | (0.41) | — | (0.42) | — | (0.12) | — | (0.81) | — | (0.40) |
| Male v. female | 1.3 | (0.004) | 1.1 | (0.41) | 1.3 | (0.42) | 1.5 | (0.12) | 1.0 | (0.81) | 1.1 | (0.40) |
| Clinical stage | — | (< 0.001) | — | (< 0.001) | — | — | — | — | — | (0.003) | — | (0.32) |
| T2 v. T1 | 3.3 | (0.001) | 2.1 | (< 0.001) | — | — | — | — | 0.3 | (0.011) | 1.9 | (0.06) |
| T3 v. T1 | 6.7 | (< 0.001) | 2.6 | (< 0.001) | — | — | — | — | 0.3 | (0.001) | 1.6 | (0.09) |
| T4 v. T1 | 12.4 | (< 0.001) | 2.7 | (< 0.001) | — | — | — | — | — | — | 1.9 | (0.08) |
| Nodal metastases | — | (< 0.001) | — | (0.005) | — | — | — | — | — | (0.09) | — | (0.50) |
| N1 v. N0 | 3.6 | (< 0.001) | 1.3 | (0.005) | — | — | — | — | 1.3 | (0.09) | 1.2 | (0.21) |
| N2 v. N0 | 3.4 | (< 0.001) | 1.7 | (0.05) | — | — | — | — | — | — | 1.4 | (0.42) |
| Metastases | (< 0.001) | (< 0.001) | — | — | — | — | — | — | — | (0.61) | ||
| M1 v. M0 | 4.8 | (< 0.001) | 2.0 | (< 0.001) | — | — | — | — | — | — | 1.2 | (0.61) |
| Tumour size, cm | 1.2 | (< 0.001) | 1.0 | (0.42) | 1.3 | (0.003) | 1.0 | (0.91) | 1.0 | (0.31) | 1.0 | (0.54) |
| Fuhrman grade | (< 0.001) | (0.001) | (0.43) | (0.73) | (< 0.001) | — | — | |||||
| II v. I | 1.3 | (0.06) | 1.0 | (1.00) | 0.7 | (0.42) | 0.7 | (0.54) | 1.5 | (0.23) | 1.1 | (0.83) |
| III v. I | 4.1 | (< 0.001) | 1.5 | (0.007) | 1.3 | (0.44) | 1.0 | (1.00) | 2.7 | (0.002) | 1.0 | (0.94) |
| IV v. I | 5.4 | (< 0.001) | 1.4 | (0.08) | 1.6 | (0.72) | 0.8 | (0.73) | 2.6 | (0.008) | 0.9 | (0.73) |
| Histological type | (0.032) | (0.52) | (0.50) | (0.72) | (0.53) | — | (0.054) | |||||
| Papillary v. clear cell | 0.8 | (0.24) | 1.0 | (0.92) | 1.1 | (0.81) | 1.3 | (0.50) | 1.2 | (0.53) | 0.7 | (0.11) |
| Chromophobe v. clear cell | 0.4 | (0.021) | 0.6 | (0.23) | — | — | 0.1 | (0.51) | 0.3 | (0.33) | 6.7 | (0.06) |
| Symptom classification | — | (< 0.001) | — | (< 0.001) | — | (< 0.001) | — | (< 0.001) | — | (0.020) | — | (0.024) |
| Local v. symptomatic | 3.2 | (< 0.001) | 1.8 | (< 0.001) | 1.8 | (0.022) | 3.1 | (0.001) | 1.5 | (0.012) | 1.5 | (0.032) |
| Systemic v asymptomatic | 5.4 | (< 0.001) | 2.2 | (< 0.001) | 5.4 | (< 0.001) | 5.7 | (< 0.001) | 1.5 | (0.021) | 1.7 | (0.005) |
RR = rate ratio.
*
Rate ratios are not shown; the predictor was coded as cubic splines.