Skip to main content
. Author manuscript; available in PMC: 2009 Apr 15.
Published in final edited form as: Bioorg Med Chem Lett. 2008 Mar 20;18(8):2549–2554. doi: 10.1016/j.bmcl.2008.03.047

Scheme 1.

Scheme 1

Synthesis of FR235222 derivatives Reagents and conditions: (a) coupling agent (TBTU (1.2 equiv), and/or HATU (0.75 equiv)), DIPEA (3 equiv), CH2Cl2 (0.1 M); (b) TFA (20%), anisole (2 equiv), CH2Cl2; (c) LiOH (4 equiv), MeOH; (d) LiOH (6 equiv), MeOH; (e) HATU (0.7 equiv), DEPBT (0.7 equiv), TBTU (0.7 equiv), DIPEA (6 equiv), THF/CH3CN/DCM (2:2:1) 0.007 M.11