Table 1.

Transcripts reported to be changed in two or more microarray studies of postmortem brain from substance users. Nine gene expression microarray studies employing human postmortem brain from substance use cases¹⁷–²⁵ were re-annotated using NCBI EntrezGene (http://www.ncbi.nlm.nih.gov/sites/gquery) using gene accession or Unigene identifiers. Transcripts, for which altered expression was reported in two or more different studies, are listed above by the official gene symbol. ▲ increased expression, ▼ decreased expression in substance use cases. Abbreviations: aPFC – anterior prefrontal cortex, dlPFC – dorsolateral prefrontal cortex, FC – frontal cortex, HIPP – hippocampus, supFC – superior frontal cortex.

REGION	HIPP	supFC	supFC	dlPFC	NAc	FC	MCTX	NAc	NAc	dlPFC	aPFC
SUBSTANCE	NIC	EtOH	EtOH	EtOH	EtOH	EtOH	EtOH	HER	COC	COC	COC/THC/PCP
REFERENCE	23	17	24	25	25	18	18	20	19	21	22
MAG	-	▽	-	-	-	▲▽	▲▽	-	-	-	-
MBP	-	▽	-	-	-	-	-	-	▽	-	-
PLP1	-	▽	▽	-	-	▲▽	▲	-	▽	▲▽	-
MOBP	-	-	-	-	-	▲	▲	-	▽	-	-
PMP22	-	▲▽	▽	▽	▽	-	-	-	-	-	-
GPM6B	-	▽	-	-	-	▲▽	▲	-	-	▲▽	-
APOD	-	▽	-	▽	-	▲▽	▲▽	-	-	-	-
CLU	-	▽	-	▲	▲	-	-	-	-	-	-
CNP	-	▲▽	▽	-	-	-	-	-	-	-	-
UGT8	-	▽	▽	-	-	-	-	-	-	-	-
ENPP2	-	▽	-	-	-	▲▽	▲▽	-	-	-	-
CLTB	-	-	-	-	-	-	-	-	▽	▲▽	-
RTN1	-	▲	-	-	-	▲▽	▲	-	-	-	-
LAMP2	-	-	▽	-	▽	-	-	-	-	-	-
FOSB	-	-	-	-	-	▲▽	▽	-	-	-	-
SOX9	-	▽	-	-	-	▽	▲▽	-	-	-	-
RPS10	-	-	-	-	-	-	-	-	▽	-	▲
GFAP	-	▽	-	-	-	▽	▲▽	-	-	-	-
SDC2	-	-	-	▲	-	▽	▲▽	-	-	-	-
CALM1	▲	-	-	-	-	-	-	-	-	-	▽
CAPN3	-	▽	▽	-	-	-	-	-	-	-	-
PPP3CB	▲	▲	-	-	-	▲▽	▽	-	-	-	-
NTRK2	-	-	-	-	-	▽	▲▽	▲	▽	-	-
GNAO1	▲	-	-	-	-	-	-	-	-	▲▽	-
GABBR1	-	-	▲	▲	-	-	-	-	-	-	-
GRIA1	▲	▲	-	-	-	-	-	-	-	-	-
SLC25A3	-	-	-	-	-	-	-	▽	▽	-	▲
SYT11	-	▲▽	-	-	-	-	-	-	-	▲▽	-
CAPRIN1	-	▲	-	-	-	-	-	-	-	-	▲
SEPT4	-	-	-	-	-	-	-	▲	▽	▲▽	-
HLA-DRB1	-	-	▽	▽	-	-	-	-	-	-	-
MST1	-	▽	-	-	-	▽	▽	-	-	-	-
APP	-	-	-	-	▽	-	-	▽	▲	-	-
YWHAH	-	-	-	-	▽	-	-	-	-	▲▽	-
PSMB2	-	-	▽	▽	-	-	-	-	-	-	-
PSMB7	-	▽	-	-	-	-	-	-	-	-	▽
AGT	-	▽	▽	-	-	-	-	-	-	-	-
TF	-	▽	▽	-	-	▲▽	▲▽	-	-	-	-