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. 2008 Aug 13;3(8):e2950. doi: 10.1371/journal.pone.0002950

Figure 4. Quantification of the attenuation with ST556 deletion mutants.

Figure 4

(A) Middle ear co-infection. Both the left and right ears of chinchillas (n = 3) were infected by tympanotomy with a 1∶1 mixture of the wild type and isogenic deletion mutants ST1594 (SP0308), ST1595 (tetM), ST1601 (SP1732, stkP) or ST1603 (SP1448). Each symbol represents the CI value from a single ear of infected chinchillas. CI is defined as the output CFU ratio (mutant/wild type) divided by the input CFU ratio (mutant/wild type). Bar indicates the geometric mean CI value for each group of chinchillas. Statistical significance was determined by Student's t test. *, P<0.05, **, P<0.01. (B) Nasal co-infection. BALB/c mice (n = 5) were intranasally infected as in (A). The data were analyzed and presented as in (A).