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Nuclear aggregates of ataxin-1 do not alter lamin B1 distribution in transfected cells. CHO cells were transfected with EGFP-tagged ataxin-1 with 82 glutamines (Atxn82Q) and stained for lamin B1. Atxn82Q forms characteristic intranuclear aggregates but the nuclear envelope or the distribution of lamin B1 are not affected. (A) EGFP fluorescence, (B) lamin B1 staining, and (C) merged signals. Scale bar = 10 μm.
