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. Author manuscript; available in PMC: 2009 Oct 3.
Published in final edited form as: J Mol Biol. 2008 Jul 7;382(2):371–384. doi: 10.1016/j.jmb.2008.06.083

Figure 4.

Figure 4

Figure 4

Figure 4

Figure 4

Peptide non-planarity in the active-site disulfide loop. a) Stereoview of the disulfide loop with standard hydrogen bonds (green dotted lines) and unusually long “hydrogen bonds” (red dotted lines) shown. b) Views down each peptide bond in the loop in GRNative visually reveal the magnitude of omega deviations from planarity, which are 4°, 13°, 7°, 10°, 5°, and 11° for residues 58–63. c) A plot of smoothed (N=5) omega deviations from planarity shows the disulfide loop (residues 59–63 in particular) as the most consistently non-planar region in GR. Omega deviations in this loop are similar in all four structures. d) Histogram of pentapeptide stretches in atomic-resolution structures with deviations from planarity (see Methods). The level of nonplanarity of this GR loop (ranging from 46° to 53° in the four GR structures) is unusual, with only two other examples of similarly deviating loops (see Results & Discussion).