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. Author manuscript; available in PMC: 2009 Oct 3.
Published in final edited form as: J Mol Biol. 2008 Jul 7;382(2):371–384. doi: 10.1016/j.jmb.2008.06.083

Figure 6.

Figure 6

Steric compression in nicotinamide-flavin interaction. Side view of overlaid active site centered on flavin, showing GRNative (green), GRGSH (magenta) and GRNADPH (cyan). In GRNADPH, NADPH binding above the flavin pushes it down into Cys63, and in GRGSH, GSH and the Cys63 thiolate below the flavin push it up. GRGSSG/NADP is not shown because its atoms are in the same positions as in GRNative. To conserve space the flavin-nicotinamide and the flavin-Cys63 separations are not to scale. Figure 8 shows these distances to scale.