Table 2.
Biodistribution in ICR mice after an iv injection of [18F]tracers in 0.1% BSA (%dose/g, avg of 3 mice ± SD)
| [18F]3e (Partition Coefficient = 1375) | ||||
|---|---|---|---|---|
| Organ | 2 min | 30 min | 1 hr | 2 hr |
| Blood | 1.79 ±0.25 | 1.65 ± 0.15 | 1.51 ±0.20 | 1.18 ±0.08 |
| Heart | 10.43 ±0.96 | 2.76 ±0.26 | 1.45 ±0.17 | 0.91 ±0.04 |
| Muscle | 0.84 ±0.30 | 1.53 ±0.30 | 1.22 ±0.20 | 0.66 ±0.13 |
| Lung | 93.40 ±16.91 | 12.93 ±4.75 | 5.00 ±0.84 | 3.74 ±0.35 |
| Kidney | 13.32 ±1.41 | 4.64 ±0.26 | 2.97 ±0.29 | 2.19 ±0.26 |
| Spleen | 4.43 ±0.26 | 2.45 ±0.22 | 1.24 ±0.11 | 0.99 ±0.14 |
| Liver | 14.13 ±0.73 | 14.65 ±1.73 | 13.46 ±2.62 | 9.51 ±1.04 |
| Skin | 0.67 ±0.02 | 1.69 ±0.38 | 1.65 ±0.15 | 1.00 ±0.07 |
| Brain | 5.55 ±0.64 | 5.21 ±0.66 | 2.97 ±0.43 | 1.37 ±0.14 |
| Bone | 1.57 ±0.12 | 2.06 ±0.35 | 6.50 ±2.92 | 8.63 ±1.78 |
| [18F]4e(Partition Coefficient = 889) | ||||
| Organ | 2 min | 30 min | 1 hr | 2 hr |
| Blood | 2.60 ±0.23 | 2.47 ±0.25 | 1.82 ±0.30 | 0.78 ±0.02 |
| Heart | 7.49 ±0.95 | 2.06 ±0.24 | 1.54 ±0.12 | 0.65 ±0.02 |
| Muscle | 0.74 ±0.11 | 1.31 ±0.45 | 0.85 ±0.41 | 0.41 ±0.04 |
| Lung | 26.13 ±1.91 | 8.90 ±1.39 | 7.51 ±1.01 | 4.15 ±0.61 |
| Kidney | 11.70 ±1.49 | 4.13 ±0.35 | 3.06 ±0.17 | 1.50 ±0.08 |
| Spleen | 5.01 ±1.64 | 2.41 ±0.57 | 1.37 ±1.08 | 1.22 ±0.34 |
| Liver | 20.61 ±2.00 | 19.60 ±1.40 | 14.58 ±1.35 | 8.14 ±2.33 |
| Skin | 0.92 ±0.23 | 1.49 ±0.25 | 1.22 ±0.21 | 0.57 ±0.08 |
| Brain | 9.75 ±1.38 | 1.70 ±0.41 | 0.72 ±0.13 | 0.31 ±0.04 |
| Bone | 1.53 ±0.32 | 2.13 ±0.19 | 5.30 ±1.94 | 7.76 ±0.29 |