Effect of L-DOPA on METH-induced neurotoxicity. L-DOPA (50 mg/kg, ip) was administered alone or 60 min prior to the first and third METH treatment and striatal DA levels were determined 2, 7, or 14 days after METH. Results are presented as mean ± SEM relative to controls. Significant differences were determined via one-way ANOVA followed by Tukey’s multiple comparison test, and are indicated as follows: *, p < 0.01 relative to control (CON); #, p < 0.01 relative to METH. Reproduced from Thomas et al.32 with permission of Blackwell Publishing.