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. Author manuscript; available in PMC: 2009 Sep 15.
Published in final edited form as: Bioorg Med Chem. 2008 Aug 7;16(18):8546–8556. doi: 10.1016/j.bmc.2008.08.007

Scheme 3.

Scheme 3

a) 7 steps13; b) TBDPS-Cl, imidazole, DMF; c) NaOH, H2O, MeOH, reflux; d) 2-mercaptopyridine N-oxide, DCC, toluene; e) (Me3Si)3SiH, AIBN, toluene; f) Bu4NF, THF; g) 2,6-dichloropurine, PPh3, DIAD, THF; h) RNH2, EtOH; i) TFA/H2O/MeOH.