Table 1.

TH, Tyrosine Hydroxylase; DA, Dopamine; VMAT, Vesicular Monoamine Transporter; DAT, Dopamine Transporter; AADC, Aromatic Amino Acid Decarboxylase; CCK, Cholecystokinin; DR, (Dopamine Receptor); SNc, Substantia Nigra, pars compacta

PD-like phenotypic findings in aphakia mice		References
Evidence for selective loss of DA containing neurons in SNc
•	Loss or reduction of DA neuron markers in nigrostriatal circuit: TH, VMAT, AADC, Drd1a, Drd3, Drd4, DAT, CCK, NTR-1, alpha-synuclein, Nurr1, D2R	Hwang-2003, Nunes-2003, Smidt-2003, Singh-2007, van den Munckhof-2003, van den Munckhof-2006, Kas-2008
•	Loss of nissl staining in SNc	Hwang-2003, Nunes-2003, Smidt-2003, van den Munckhof-2003
•	Loss of DA content in dorsal striatum as measured by HPLC/voltammetry	Hwang-2003, van den Munckhof-2003, Nunes-2003, Kas-2008
•	Loss of retrograde labeling when fluorogold is injected into dorsal striatum	Hwang-2003, Nunes-2003, Smidt-2003,
•	Increase in enkephalin mRNA expression, decrease in neurotensin mRNA expression	van den Munckhof-2006
Evidence for PD-like motor deficits in aphakia mice
•	Impairments in rotarod, balance beam, pole test, string test, cotton shred, hind-limb stepping, spontaneous locomotor activity	Hwang-2005, Singh-2007, van den Munckhof-2006,
Evidence for responsivity to L-Dopa
•	Reversal of motor deficits by acute L-Dopa	Hwang-2005, van den Munckhof-2006
•	dyskinesia-like behavioral and biochemical alterations in response to chronic L-Dopa	Ding 2007
•	Increase in c-fos in the dorsal striatum in response to acute L-Dopa (indicative of denervations supersensitivity)	Hwang-2005