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. Author manuscript; available in PMC: 2008 Dec 4.
Published in final edited form as: Nat Cell Biol. 2008 May 30;10(7):825–836. doi: 10.1038/ncb1744

Figure 7.

Figure 7

Senescence increases in BubR1H/H tissues with high p16Ink4a when p19Arf is lacking. (a) IAT of 2-month-old BubR1H/H and BubR1H/H;p19Arf−/− mice stained for SA-β-galactosidase activity. Scale bar is 2 mm. (b) Relative expression of senescence markers in gastrocnemius muscles of 6-week-old wild-type, p19Arf−/−, BubR1H/H and BubR1H/H;p19Arf−/− mice. All values were normalized to GAPDH. Relative fold expression is to wild-type gastrocnemius. Data are mean ± s.d. (n = 3 male mice were evaluated per genotype). (c) Replicative senescence in skeletal muscle and fat of 2-month-old wild-type, BubR1H/H and BubR1H/H;p19Arf−/− mice as analysed by in vivo BrdU incorporation. Data are mean ± s.d. (n = 3 male mice per genotype were used for this experiment).