Figure 8.

Ablation of p16^Ink4a accelerates lung tumorigenesis in BubR1 insufficient mice. (a) Percentage of mice with tumours at time of death as a function of time for p16^Ink4a−/−, BubR1^H/H and BubR1^H/H;p16^Ink4a−/− mice. Biopsies were performed on moribund animals and all tissues were screened for tumours. Tumour tissues were collected and processed for histological confirmation. The BubR1^H/H;p16^Ink4a−/− curve is significantly different from the BubR1^H/H curve with P = 0.0027 (calculated using a log-rank test). (b) Tumour spectra of p16^Ink4a−/−, BubR1^H/H and BubR1^H/H;p16^Ink4a−/− mice. (c) As in a but for p19^Arf−/−, BubR1^H/H and BubR1^H/H;p19^Arf−/− mice. There is no significant difference between the curves of BubR1^H/H;p19^Arf−/− and p19^Arf−/− mice using a log-rank test.