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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Exp Mol Pathol. 2008 Apr 8;85(1):11–19. doi: 10.1016/j.yexmp.2008.03.007

Figure 2.

Figure 2

Iron acquisition. Both host and pathogen compete for iron and have evolved multiple strategies to outdo the other. The bacterial siderophore enterobactin sequesters iron with high affinity, while host lipochalin 2 binds enterobactin and prevents its uptake by UPEC. Bacteria carrying the iroA gene cluster can modify enterobactin by glucosylation, creating salmochelin, which effectively binds iron but is not recognized by lipochalin 2.