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Comparison of craniofacial skeletons among E15.5 Ednra-null (EdnralacZ/lacZ) (A), wild-type (B) and Edn1-misexpressing (EdnraEdn1/+) (C) mice. Activated Edn1/Ednra signaling (colored in pink) correlates to the formation of MC and associated mandibular structures. at, ala temporalis; dnt, dentary; hy, hyoid; in, incus; ma, malleus; mx, maxilla; pl, palatine; pmx, premaxilla; *, ectopic structure.
