Table 2.

Effect of Baseline Tiredness on 10-Year Survival in the Full Cohort and Key Subgroups

Full Cohort Models		Hazard Ratio (95% CI)	p-value
1 Unadjusted		1.86 (1.44-2.41)	<0.001
2 Adjusted for age, gender, race, education		1.94 (1.49-2.53)	<0.001
3 Model 2 plus BMI, MMSE, cardiovascular disease, neurological disease, diabetes, cancer, musculoskeletal disease, pulmonary disease, ophthalmologic disease, depressive symptoms, sleep problems, chronic pain		1.69 (1.27-2.25)	<0.001
4 Model 3 plus self-rated health, SF-36 PFI, NIH ADL, and gait speed*		1.44 (1.08-1.93)	0.01
Fully Adjusted Models for Key Subgroups
Age:	< 75 years (n=212)	1.53 (0.99-2.39)	0.06
	≥ 75 years (n=280)	1.51 (1.01-2.27)	0.05
Gender:	Men (n=276)	1.60 (1.10-2.34)	0.01
	Women (n=216)	1.52 (0.94-2.48)	0.09
Race:	White (n=394)	1.39 (1.01-1.90)	0.04
	Non-white (n=98)	2.91 (1.33-6.42)	0.008
Comorbid	≤ 2 (n=275)	1.48 (0.93-2.36)	0.10
conditions:	> 2 (n=217)	1.38 (0.93-2.04)	0.10
Functional	No difficulty with ADLs or IADLs (n=197)	0.85 (0.47-1.54)	0.58
Status:	Difficulty with ≥ 1 ADL or IADL (n=295)	1.85 (1.28-2.66)	0.001
Gait speed:	< 1 meter/second (n=337)	1.39 (1.00-1.94)	0.05
	≥ 1 meter/second (n=155)	1.63 (0.73-3.63)	0.24

BMI: Body mass index; MMSE: Mini-mental State Exam; NHIS ADL: National Health Interview Survey Activities of Daily Living; SF-36 PFI: Medical Outcomes Survey Physical Function Index; ADL: Instrumental Activities of Daily Living; IADL: Instrumental Activities of Daily Living

^*The other significant predictors of mortality (and HRs per unit increase) in the fully adjusted model were age (1.05), female gender (0.69), white race (1.79), BMI (0.95), cardiovascular disease (1.57), diabetes (1.42), lung disease (1.47), chronic pain (1.77), gait speed (0.39), and the SF-36 PFI (0.99).