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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Virology. 2008 Jun 30;378(2):292–298. doi: 10.1016/j.virol.2008.05.015

Figure 7.

Figure 7

Estradiol treatment reduces myocarditis and increases FoxP3+ T regulatory cell response in female mice. Vaginal smears were done on TNF1.6 mice and the animals were immediately infected with 105 PFU CVB3. On days +1 and +3 relative to infection, mice were injected i.p. with 200 ng estradiol in PBS or PBS alone. Animals were killed 7 days after infection. Hearts were evaluated for virus titer and cardiac inflammation. PBMC were isolated from individual animals and evaluated for FoxP3+ T cells by flow cytometry. Results represent mean ± SEM of 4 to 6 mice/group. * Significantly different from mice in same estrus phase and treated with PBS at p< 0.05. ** Significantly different from mice in same estrus phase and treated with PBS at p≤ 0.01.