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Effect of immediate heart treatment on the sensitivity to 5-FU, oxalipalatin and irinotecan. HT29 (A) and HCT116 (B) cells were subjected to various concentrations of a drug, immediately followed by heat treatment at 37° (○) 42° (•) and 45°C (▾) for 15, min, Drugs were removed from medium after 24 h. Cell viability was determined by MTT assay 72 h after heat treatment. Data are shown as mean ± SD. Cell survival for each temperature was corrected for heat cytotoxicity.
