TABLE 3.
Effect of subcutaneous treatment with NaDMDC on TH immunoreactivity (IR) fiber density in striatal subregions and stereological estimates of TH-IR neurons in the SNc
DL, dorsolateral; DM, dorsomedial; VL, ventrolateral; VM, ventromedial.
|
Region |
Mean ± S.E. (n = 5) |
|||
|---|---|---|---|---|
|
2W |
2 + 9W |
|||
| Control | Treated | Control | Treated | |
| TH-IR fiber density | ||||
| DL striatum | 1515 ± 207 | 1456 ± 221 | 1934 ± 299 | 1951 ± 269 |
| DM striatum | 1048 ± 149 | 843 ± 117 | 1435 ± 199 | 1358 ± 130 |
| VL striatum | 1439 ± 142 | 1290 ± 140 | 1833 ± 254 | 1409 ± 166a |
|
VM striatum |
815 ± 103 |
696 ± 62 |
1073 ± 174 |
946 ± 152 |
| TH-IR-positive neurons | ||||
| SNc | 7980 ± 491 | 7832 ± 574 | 8251 ± 214 | 7897 ± 247 |
a
p ≤ 0.05 compared with corresponding region in control mice at the same time point; ANOVA followed by Fisher PLSD.