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WDR5-MLL interactions. A and B, detailed interactions between WDR5 and MLL peptide and comparison with the WDR5-H3K4me2 interaction. C, GST pull-down experiments with GST-MLL228 mutants and WDR5. Mutating Arg-2 in histone H3-like motif significantly decreased the binding ability of MLL for WDR5. D, GST pull-down experiments with GST-MLL228 and WDR5 mutants.
