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. 2008 Dec 16;3(12):e3947. doi: 10.1371/journal.pone.0003947

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Stiefel et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Left column: control conditions. Center column: bath application of carbachol. Right column: difference between the charbachol and control conditions. Top plots: raw data. Bottom plots: mean±s.e.m. of binned data. Filled symbols: significant changes in comparison to the ISIs without a perturbation. Data from example neurons (A) showing a transition from a type II to a type I PRC and (B) remaining with a type I PRC. Insets: voltage averages of the perturbing pulses in the absence (thin line) and presence (thick line) of carbachol. Average amplitudes were (A) 3.2/3.5 mV (54/60 sweeps) and (B) 3.2/3.8 mV (67/67 sweeps).