Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2008 Dec 16;3(12):e3945. doi: 10.1371/journal.pone.0003945

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Kawakita et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

A–C: FL, HL/FL, and body weight (BW) of alpha7 nAChR −/− and alpha7 nAChR +/+ E15.5 littermate fetuses. Alpha7 nAChR +/− female were mated with alpha7 nAChR +/− male, and given drinking water with or without nicotine during pregnancy. Relative FL, HL/FL, and BW were calculated, each value in mice that did not receive nicotine was regarded as equal to 1.0. Nicotine significantly reduced FL and HL/FL in alpha7 nAChR +/+ fetuses but not in alpha7 nAChR −/− fetuses (A,B). Nicotine did not significantly reduce BW in either genotype (C). D: Scatterplot and correlation between the FL and BW of mice with (red line) or without (black line) exposure to nicotine. In alpha7 nAChR +/+ fetus, Nicotine downwardly shifts the linear slope in alpha7 nAChR +/+ fetuses but not in alpha7 nAChR −/− fetuses.