Table 5.
Reminder Plus Education With or Without Risk Assessment*
| Study | Intervention component (target of intervention) | Outcomes | Event rates (intervention vs. control) | Relative risk† (95% CI) |
|---|---|---|---|---|
| Feldstein‡ (2006)34 | Reminder (Phys & Pts) + Ed (Pts) | BMD testing or initiation of OP medication | 51% vs. 6% | 8.67 (3.90 to 19.26)§∥ |
| 43% vs. 6% | 7.26 (3.24 to 16.24)§∥ | |||
| Gardner‡ (2005)35 | Reminder (Phys & Pts) + Ed (Pts) | OP addressed (BMD or OP therapy) | 42% vs. 19% | 2.14 (1.00 to 4.62)§∥ |
| Solomon (2007)42 | Reminder (Phys & Pts) + Ed (Phys, Pharmacists, & Pts) | BMD testing | 13% vs. 9% | 1.43 (1.11 to 1.86)§∥ |
| OP medication | 6% vs. 4% | 1.60 (1.07 to 2.41)§∥ | ||
| McDonough (2005)37 | Reminder (Phys) + Ed (Pharmacists & Pts) | BMD testing | 72% vs. 63% | 1.14 (0.78 to 1.67) |
| Bisphosphonate therapy | 26% vs. 10% | 2.49 (0.63 to 9.87) | ||
| Calcium intake | 56% vs. 32% | 1.77 (0.88 to 3.55) | ||
| Solomon (2004)40 | Reminder (Phys) + Ed (Phys) | BMD testing | 32% vs. 38% | 0.84 (0.64 to 1.12)§ |
| OP medications | 8% vs. 8% | 0.99 (0.49 to 2.00)§∥ | ||
| Solomon (2006)41 | Reminder (Pts) + Ed (Pts) | BMD testing | 46% vs. 42% | 1.09 (0.91 to 1.30)∥ |
| Calcium intake | 68% vs. 69% | 0.98 (0.89 to 1.09)∥ | ||
| LaCroix (2005)36 | Reminder (Phys & Pts) + Ed (Pts) + RA (SCORE) (Pts) | Any fracture | 9% vs. 12% | 0.77 (0.52 to 1.12) |
| Initiation of any therapy | 21% vs. 20% | 1.05 (0.82 to 1.35) | ||
| Reminder (Phys & Pts) + Ed (Pts) + RA (SOF) (Pts) | Any fracture | 9% vs. 9% | 0.96 (0.69 to 1.34) | |
| Initiation of any therapy | 21 vs. 17% | 1.27 (1.03 to 1.56)§ | ||
| Morrison (2004)38 | Reminder (Phys) + Ed (Pts) + RA (Pts) | Prescription of bisphosphonates | Both groups increased in the prescription of bisphosphonates by 50% (p < 0.001), but no difference between groups for outcome | |
*CI = confidence interval; Phys = physician; Pts = patients; Ed = education; BMD = bone mineral density; OP = osteoporosis; RA = risk assessment; SCORE = simple calculated osteoporosis risk estimation; SOF = study of osteoporotic fracture
†Using random effects model, relative risk with 95% confidence intervals was calculated from event rates using Cochrane Review Manager 4.2.8
‡Study indicated all of: method of randomization sequence and concealment, blinding, follow-up, and ≥80% follow-up
§Significant
∥Data verified by author